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⦿ Abdominal bloating or swelling: Persistent bloating that doesn't go away after eating.
⦿ Pelvic or abdominal pain: A dull, persistent pain or discomfort in the pelvic or lower abdomen.
⦿ Difficulty eating or feeling full quickly: Feeling full after eating only a small amount of food.
⦿ Urinary urgency or frequency: A constant need to urinate or frequent trips to the bathroom.
⦿ Fatigue or feeling tired all the time: Unexplained exhaustion or lack of energy, even with rest.
⦿ Unexplained weight loss or gain: Sudden weight changes without changes in diet or activity levels.
⦿ Changes in bowel habits, such as constipation: Difficulty with bowel movements, often due to bloating or pressure.
⦿ Back pain: Persistent lower back pain not related to physical activity.
⦿ Menstrual irregularities or abnormal bleeding: Unusual or heavy menstrual bleeding, or changes in menstrual cycles.
⦿ Pain during intercourse: Pain or discomfort during sexual activity due to pelvic issues.
⦿ Family history of ovarian or breast cancer: A higher risk if close relatives have had ovarian or breast cancer.
⦿ Inherited gene mutations (e.g., BRCA1, BRCA2): Genetic mutations can increase susceptibility to ovarian cancer.
⦿ Age (risk increases after menopause): Women over 50 have a higher risk, particularly after menopause.
⦿ Hormone replacement therapy (HRT) use: Prolonged use of hormone therapy after menopause may increase risk.
⦿ History of endometriosis: A condition where tissue similar to the uterine lining grows outside the uterus, increasing ovarian cancer risk.
⦿ Personal history of breast or colorectal cancer: Previous cancer history can increase the risk of developing ovarian cancer.
⦿ Obesity: Being overweight or obese raises the risk of ovarian cancer due to hormonal changes.
⦿ Smoking and excessive alcohol consumption: Lifestyle factors like smoking and drinking can increase ovarian cancer risk.
⦿ Never being pregnant or having difficulty conceiving: Infertility and not having children may slightly increase risk.
⦿ Pelvic examination to feel for abnormal masses: A physical check for any unusual lumps or swelling in the pelvic area.
⦿ Transvaginal ultrasound to check for tumors or abnormalities: An ultrasound used to get a clearer view of the ovaries and detect abnormalities.
⦿ CA-125 blood test to detect elevated tumor marker levels: A blood test to measure the CA-125 protein, often elevated in ovarian cancer.
⦿ CT scan or MRI to evaluate the size and spread of tumors: Imaging techniques to determine how far cancer has spread and its size.
⦿ Biopsy to confirm cancerous cells: A tissue sample is taken to confirm the presence of cancer cells in the ovary.
⦿ Laparoscopy to examine the pelvic area and take tissue samples: A minimally invasive procedure for visualizing the abdominal organs and collecting tissue for testing.
⦿ Surgery to remove the ovaries, fallopian tubes, and other affected tissues: Surgical removal of the ovaries and affected organs to control cancer spread.
⦿ Chemotherapy to destroy cancer cells or shrink tumors: The use of drugs to kill cancer cells or reduce tumor size, often following surgery.
⦿ Targeted therapy to block cancer cell growth: Drugs that target specific molecules to prevent cancer cells from growing or spreading.
⦿ Hormone therapy to block hormone-related tumor growth: Medications to block or reduce hormones that fuel the growth of some ovarian cancers.
⦿ Immunotherapy to boost the body’s immune system against cancer: Treatment that helps the immune system identify and attack cancer cells.
⦿ Radiation therapy, though less commonly used, may be considered: High-energy rays used to target and shrink tumors, usually in advanced cases.
⦿ Clinical trials to explore new treatment options: Participation in trials to test the effectiveness of new therapies and medications.
Treatment Option | Description | Purpose | Outcome/Effectiveness | Side Effects |
---|---|---|---|---|
Surgery (Oophorectomy) | Removal of ovaries, fallopian tubes, and surrounding tissues to eliminate cancer. | To remove cancerous tissue and reduce the spread of the disease. | Effective for localized cancer; improves survival if the cancer is contained. | Pain, infection, bleeding, hormonal changes. |
Chemotherapy | Use of drugs to kill cancer cells or shrink tumors. | To destroy remaining cancer cells after surgery or reduce tumor size. | Can significantly shrink tumors, often used as adjuvant therapy. | Nausea, fatigue, hair loss, immune suppression. |
Targeted Therapy | Drugs that target specific cancer cells without harming normal cells. | To inhibit cancer cell growth by targeting molecular abnormalities. | Effective in some cases, particularly for cancers with specific mutations. | Diarrhea, fatigue, skin problems. |
Hormone Therapy | Treatment to block hormones that fuel tumor growth. | To slow or stop the growth of hormone-sensitive cancers. | Used when cancer is hormone-receptor positive; can manage recurrence. | Hot flashes, mood swings, fatigue. |
Immunotherapy | Treatment that boosts the body’s immune system to fight cancer. | To enhance immune response against cancer cells. | Still experimental for ovarian cancer, but promising in some cases. | Fatigue, immune-related side effects, rashes. |
Radiation Therapy | High-energy radiation used to target cancer cells. | To shrink or eliminate residual cancer cells. | Less commonly used; may be effective for localized spread. | Skin irritation, fatigue, nausea. |
Clinical Trials | Participation in studies for new treatment options. | To test new therapies and treatments for effectiveness. | Can offer access to innovative treatments and better outcomes. | Side effects vary depending on the trial treatment. |
Common symptoms include abdominal bloating, pelvic pain, difficulty eating, and urinary changes, but they can be similar to other conditions.
Ovarian cancer is diagnosed through pelvic exams, blood tests (like CA-125), ultrasounds, and sometimes biopsy or CT scans for confirmation.
Treatment typically involves surgery to remove tumors, followed by chemotherapy, targeted therapy, or hormone therapy based on the cancer's characteristics.
While it cannot be fully prevented, genetic counseling, early detection, and reducing risk factors (like obesity) may help lower the chances.
The survival rate depends on the stage at diagnosis; early-stage ovarian cancer has a higher survival rate compared to advanced stages.
Risk factors include family history, age, hormonal therapy, and conditions like endometriosis, with genetic mutations like BRCA1 and BRCA2 also increasing risk.
Yes, ovarian cancer can recur, especially if it was diagnosed at an advanced stage; regular follow-ups are crucial for early detection of recurrence.
Treatment, particularly surgery and chemotherapy, can affect fertility, but options like egg freezing or fertility preservation may be discussed before starting treatment.
While some alternative therapies may help manage symptoms, they should not replace conventional treatments like surgery and chemotherapy; always consult with your doctor first.
Genetic testing can help identify hereditary risk factors like BRCA mutations, guiding personalized treatment and potential preventive options for family members.
Dr. Swati Shah is a renowned Robotic Uro and Gynecological Cancer Surgeon from Ahmedabad. He has 15+ years of extensive experience in pelvic oncosurgery and 10+ years of experience in robotic surgery. She treats cancers of kidney, bladder, prostate, uterus, ovaries and other pelvic organs.