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Hormone Therapy After Radiation Helps Prevent Prostate Cancer from Spreading

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Hormone Therapy After Radiation Helps Prevent Prostate Cancer from Spreading

A new large analysis has shown that adding hormone therapy to radiation treatment after surgery can help keep prostate cancer from spreading and lower the risk of dying from the disease. The study, called DADSPORT, combined data from five major clinical trials involving more than 4,400 men with nonmetastatic prostate cancer — cancer that has not spread to other organs.

All the men had undergone prostate surgery and then received postoperative radiotherapy to reduce the chance of the cancer returning. Some also received androgen suppression therapy, which lowers testosterone levels and helps slow cancer growth.

The results showed that men who had both treatments had better outcomes. Hormone therapy reduced the risk of the cancer spreading and improved metastasis-free survival and prostate cancer–specific survival by about 4% at eight years. The improvement in overall survival — living longer from any cause — was smaller but still meaningful for men at higher risk of recurrence.

The benefit appeared greatest in men with higher PSA levels before radiation or those with more aggressive disease after surgery.

These findings support the use of hormone therapy alongside radiation after surgery, especially for men with high-risk features. For lower-risk patients, the small survival benefit may not outweigh side effects, so decisions should be personalized.

This study helps clarify one of the long-standing questions in prostate cancer care — showing that hormone therapy can make postoperative radiation more effective at keeping the disease under control.

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