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Testicular Cancer Symptoms, Diagnosis and Tumour Markers

Testicular Lump? Understand Your Ultrasound, CT Scan and Blood Reports

A new lump, swelling, enlargement or change in the feel of a testicle should be medically assessed. Testicular cancer may present as a painless lump, so absence of pain does not rule it out.

Reports may contain phrases such as “intratesticular lesion,” “solid hypoechoic mass,” “increased vascularity,” “retroperitoneal lymphadenopathy,” “para-aortic nodes” or “residual retroperitoneal mass.” These are descriptions of findings, not a diagnosis by themselves. They must be interpreted with the images, examination, tumour markers and clinical history.

Dr. Swati H. Shah is a uro- and gynaecologic oncosurgeon in Ahmedabad with a surgical interest in testicular cancer and complex retroperitoneal disease.

Symptoms That Should Be Checked

Possible symptoms include:

  • A painless lump or firm area in one testicle.
  • Testicular swelling, enlargement or a change in size, shape or consistency.
  • A feeling of heaviness in the scrotum.
  • Dull ache or discomfort in the testicle, scrotum, groin or lower abdomen.
  • A sudden collection of fluid around the testicle.
  • Persistent back pain, abdominal discomfort or abdominal swelling, which may require assessment in context.

These symptoms can also occur with non-cancerous conditions. A new or persistent lump should be assessed rather than self-diagnosed. Sudden, severe testicular pain requires emergency assessment, as testicular torsion can compromise the blood supply.

Scrotal Ultrasound: What Words May Appear in the Report?

Scrotal ultrasound may also be called USG scrotum, ultrasound scrotum or testicular ultrasound. It helps determine whether a finding is inside the testicle or in surrounding structures and describes its size, appearance and blood flow. The phrases below are examples of common report language—not a diagnostic checklist.

Location and type of lesion:

  • Intratesticular lesion / intratesticular mass: abnormality within the testicular tissue.
  • Solid intratesticular lesion / solid testicular mass: a solid-appearing finding within the testicle that needs prompt specialist assessment.
  • Focal testicular lesion / focal lesion in testicular parenchyma: a localised abnormal area.
  • Testicular mass / testicular tumour / space-occupying lesion (SOL): general terms for an abnormal area occupying space.
  • Unilateral testicular lesion: affecting one testicle.
  • Bilateral testicular lesions: abnormalities described in both testicles.
  • Upper-pole / mid-pole / lower-pole lesion: location within the testicle.
  • Multifocal lesions: more than one separate lesion.
  • Intra- versus extra-testicular lesion: whether the finding arises within the testicle or outside it, a distinction that can help guide assessment.
  • Paratesticular mass: a mass arising in structures around the testicle rather than in the testicular tissue itself.

Echogenicity, texture and margins:

  • Hypoechoic lesion / hypoechoic mass: appears darker than surrounding tissue on ultrasound.
  • Heterogeneously hypoechoic mass: has mixed internal appearance and is darker overall than surrounding tissue.
  • Hyperechoic / echogenic focus: appears brighter on ultrasound.
  • Isoechoic lesion: has similar brightness to surrounding tissue.
  • Homogeneous / heterogeneous echotexture: uniform / mixed internal ultrasound appearance.
  • Well-defined / well-circumscribed margins: the edge is clearly seen.
  • Ill-defined margins / irregular margins / lobulated lesion: describes the outline of the finding.
  • Mixed solid-cystic lesion / complex mass: contains both solid-appearing and fluid-containing components.
  • Cystic areas / internal cystic components: fluid-containing portions within a lesion.
  • Calcific foci / intralesional calcification / microcalcifications: small or larger calcium deposits.
  • Necrotic areas / areas of necrosis / haemorrhagic areas: areas that may reflect tissue breakdown or bleeding, depending on context.
  • Posterior acoustic enhancement: increased echoes behind a fluid-containing structure, a feature often described with cysts.

Ultrasound cannot reliably identify every tumour subtype. A report’s description of shape or echogenicity should not be treated as a definitive histological diagnosis.

Colour Doppler and blood flow:

Common phrases include:

  • Increased internal vascularity / internal vascular flow.
  • Peripheral vascularity.
  • Marked intralesional vascularity / hypervascular lesion.
  • Low-level internal flow.
  • No significant internal vascularity detected.
  • Normal vascularity of both testes.
  • Reduced / absent intratesticular vascularity.
  • Colour Doppler flow within the lesion.

Doppler assesses blood flow. Increased vascularity can be seen in a solid lesion, but it does not prove cancer. Conversely, lack of detectable flow does not automatically mean that a lesion is harmless.

Other scrotal findings that may appear in the report:

  • Hydrocele / reactive hydrocele: fluid around the testicle.
  • Epididymal cyst / spermatocele: cystic lesion near the epididymis.
  • Varicocele: enlarged veins in the scrotum.
  • Epididymal enlargement / hypervascularity: may occur with inflammation.
  • Features suggestive of epididymo-orchitis: findings that may support inflammation or infection.
  • Scrotal wall thickening.
  • Testicular microlithiasis: tiny calcifications within testicular tissue; not the same as a tumour.
  • No focal intratesticular lesion identified.
  • No evidence of torsion: a phrase used when torsion has been assessed, though sudden severe pain still needs urgent clinical assessment.

Phrases in the ultrasound “Impression” or “Conclusion”:

  • “Solid intratesticular lesions; neoplasm cannot be excluded.”
  • “Suspicious testicular mass.”
  • “Features concerning testicular neoplasm.”
  • “Indeterminate intratesticular lesion.”
  • “Clinical correlation advised.”
  • “Correlate with serum tumour markers.”
  • “Urgent urology / specialist consultation recommended.”
  • “Further imaging / staging work-up may be considered.”

If a report describes a suspicious solid intratesticular mass, arrange prompt specialist review. “Neoplasm cannot be excluded” does not confirm cancer, but it means the finding needs appropriate assessment.

CT Scan for Testicular Cancer: What May Be Written?

Scrotal ultrasound is the first-line imaging test for a suspected testicular mass. CT chest, abdomen and pelvis may be used for staging when testicular cancer is suspected or confirmed, to assess lymph nodes and possible spread. The imaging plan depends on the clinical situation.

Retroperitoneal lymph nodes:

The retroperitoneum is the deep space at the back of the abdomen. CT reports may use these terms:

  • Retroperitoneal lymphadenopathy: enlarged lymph nodes in the retroperitoneum.
  • Para-aortic / preaortic lymph nodes: nodes near or in front of the aorta.
  • Paracaval lymph nodes: nodes near the inferior vena cava (IVC).
  • Interaortocaval nodes / aortocaval lymph nodes: nodes in the region between or near the aorta and IVC.
  • Left para-aortic nodal disease / right paracaval nodal disease: location-specific descriptions.
  • Multiple enlarged retroperitoneal lymph nodes.
  • Bulky retroperitoneal lymphadenopathy.
  • Confluent nodal mass / nodal conglomerate: nodes appearing joined into a larger mass.
  • Necrotic lymph nodes / central necrosis.
  • Pathologically enlarged / suspicious retroperitoneal nodes.
  • No significant retroperitoneal lymphadenopathy.

Enlarged nodes can have different causes. In a patient with testicular cancer, their location, size, appearance and distribution are interpreted with tumour markers, histopathology and the overall staging work-up.

Size, location and relation to vessels or organs:

Reports may say:

  • “Nodal mass measures ___ × ___ × ___ cm.”
  • “Mass in the left para-aortic / interaortocaval region.”
  • “Mass abutting the aorta / inferior vena cava.”
  • “Mass encasing or surrounding the aorta / IVC.”
  • “Loss of fat plane with adjacent structures.”
  • “Mass displacing the renal vessels / ureter / bowel.”
  • “Close relationship to the renal hilum.”
  • “Extension to the level of the renal vessels.”
  • “Vascular involvement cannot be excluded.”
  • “Hydronephrosis due to ureteric compression.”

These phrases are not interchangeable. “Abutting,” “displacing,” “encasing” and “invading” describe different relationships and need review of the actual images. Such details can be important when planning complex retroperitoneal surgery.

Other findings in a staging CT:

Depending on the case, a report may mention:

  • Pulmonary nodules / lung nodules.
  • Mediastinal lymphadenopathy.
  • Supraclavicular lymph nodes.
  • Liver lesions.
  • Bone lesions / sclerotic foci.
  • Peritoneal nodules / omental deposits.
  • Hydronephrosis.
  • No CT evidence of thoracic metastases.
  • No evidence of distant metastatic disease.
  • Findings suspicious for metastatic disease.

Not every small nodule or lesion is cancer. Each finding must be interpreted in the context of the complete scan, prior images and clinical history.

CT after chemotherapy: residual mass

Reports after treatment may include:

  • Residual retroperitoneal mass / residual nodal mass.
  • Persistent retroperitoneal lymphadenopathy.
  • Residual soft-tissue lesion.
  • Partially regressed nodal mass.
  • Interval reduction in size.
  • Stable residual mass / no significant interval change.
  • Calcified retroperitoneal mass / coarse calcification.
  • Interval increase in size / progressive enlargement.
  • Post-treatment changes.

A residual mass does not automatically mean active cancer, and it should not automatically be assumed to be scar tissue. Depending on the tumour type, tumour-marker trend, size and response to treatment, it may contain mature teratoma, viable tumour or non-viable tissue. The treating team determines whether surveillance, further treatment or surgery is appropriate.

A “burned-out” testicular tumour:

In some cases, imaging may show retroperitoneal lymph-node disease while the original testicular tumour is no longer clearly visible. Ultrasound may describe a small scar-like area, focal calcification, atrophy or an area suspicious for a regressed (“burned-out”) primary tumour. This term requires specialist interpretation; it cannot be diagnosed from one phrase alone.

Blood Tests: AFP, Beta-hCG and LDH

The main serum tumour markers used in testicular germ cell tumours are:

  • AFP — alpha-fetoprotein: may be raised in certain non-seminomatous germ cell tumours. It is not expected to be raised in a pure seminoma. Some liver conditions can also elevate AFP.
  • Beta-hCG — beta-human chorionic gonadotropin: may be raised in some seminomas and non-seminomatous germ cell tumours.
  • LDH — lactate dehydrogenase: a non-specific marker that can contribute to assessment of disease burden but cannot diagnose cancer on its own.

Normal markers do not rule out testicular cancer. Raised markers alone do not establish the diagnosis or stage. Results are interpreted with ultrasound, examination, histopathology and staging scans. Markers are usually checked before treatment and may be repeated afterwards and during follow-up.

Does a Testicular Lump Always Mean Cancer?

No. Hydrocele, epididymal cyst, spermatocele, varicocele and inflammation or infection can cause scrotal symptoms. Ultrasound helps determine whether a finding is within the testicle or in surrounding structures.

A new solid intratesticular mass needs prompt specialist assessment. Do not make a diagnosis from a report phrase alone.

Is a Needle Biopsy Needed Before Surgery?

For a solid mass suspicious for testicular cancer, the standard approach is generally high inguinal orchidectomy, rather than a needle biopsy through the scrotum. The affected testicle and spermatic cord are removed through an inguinal incision, and the tissue is examined by a pathologist. The specialist determines the plan based on examination, ultrasound and the clinical picture.

Case Example: Testicular Lump With Raised AFP

In a case featured in Dr. Swati Shah’s testicular cancer case gallery, a young patient presented with rapidly progressive testicular swelling and abdominal discomfort. Assessment identified a testicular lesion and markedly elevated AFP. The patient underwent left high inguinal orchidectomy, with histopathology and staging informing further management.

Learning point: Ultrasound, tumour markers and histopathology answer different questions. No single test should be interpreted in isolation.

Testis Cancer Case Summary: https://drswatishah.in/gallery/case-summaries/case-summaries-of-testicular-cancer/

What Should You Do If Your Report Uses These Terms?

If your ultrasound mentions a solid intratesticular lesion, hypoechoic mass, heterogeneous testicular mass, internal vascularity or suspicious testicular neoplasm, arrange prompt specialist assessment.

If CT mentions retroperitoneal lymphadenopathy, para-aortic nodes, interaortocaval lymph nodes, bulky nodal disease or residual retroperitoneal mass, bring the report and the actual scan images for review.

Bring, where available:

  • Scrotal ultrasound report and images.
  • CT chest, abdomen and pelvis report and images.
  • AFP, beta-hCG and LDH results, including dates.
  • Histopathology and previous operative notes, if surgery has occurred.
  • Chemotherapy records and previous scans, if applicable.

Frequently Asked Questions

It means ultrasound has identified a solid-appearing abnormality within the testicle. It needs prompt assessment because some solid intratesticular lesions are malignant, although the phrase alone does not confirm cancer.

The area appears darker than surrounding tissue on ultrasound. It describes appearance, not the final diagnosis.

Doppler ultrasound has detected increased blood flow in or around an area. This can occur in different conditions and is not proof of cancer by itself.

It means enlarged lymph nodes in the deep space at the back of the abdomen. In testicular cancer, their location and appearance may be relevant to staging.

Para-aortic nodes lie near the aorta; interaortocaval nodes lie between the aorta and IVC. Their appearance and distribution can be important when assessing possible spread.

A mass remains visible on imaging after treatment. It may contain mature teratoma, viable tumour or non-viable tissue. Further management depends on the tumour type, markers, scan findings and specialist review.

Yes. Normal markers do not exclude cancer. A suspicious examination or ultrasound still needs appropriate assessment.

The imaging findings do not confidently rule out a tumour. It is not a confirmed cancer diagnosis, but it warrants appropriate specialist review.

Tumour markers in testicular cancer

MarkerTypically raised inHalf-life after orchidectomy
AFPYolk sac tumour and other non-seminomatous elements; not in pure seminomaAbout 5 to 7 days
Beta-hCGChoriocarcinoma and embryonal elements; mildly in some seminomasAbout 1 to 3 days
LDHLarger tumour burden; not specificSlower fall

Frequently asked questions

Which blood tests are used for testicular cancer?

AFP, beta-hCG and LDH are the serum tumour markers. They help with diagnosis, staging and prognosis, and are repeated after orchidectomy to track response. Normal markers do not exclude cancer.

Does every testicular lump mean cancer?

No. Hydrocele, epididymal cyst, spermatocele, varicocele and epididymo-orchitis are common. Scrotal ultrasound separates a solid intratesticular mass from these.

Which imaging comes first?

Scrotal ultrasound with Doppler is first-line. CT of the chest, abdomen and pelvis is used for staging once a germ-cell tumour is suspected or confirmed.

Surgery video, short videos, patient testimonials and case summaries

Selected videos and anonymised case summaries from Dr Swati Shah’s testicular cancer practice, shared for patient education. Every patient’s plan is individual, and a past case does not predict an individual result.

Robotic RPLND surgery video

Patient-education short videos

When a testicular tumour is suspected, the surgical approach is extremely important. A scrotal incision should generally be avoided because it can disrupt the normal lymphatic drainage pathways of the testis and potentially increase the risk of local tumour contamination and altered patterns of spread.

The standard oncological procedure for a suspected testicular malignancy is high inguinal orchidectomy. Through an inguinal approach, the testis is delivered and removed along with the spermatic cord and its vascular and lymphatic pedicle, providing appropriate oncological control and allowing accurate histopathological diagnosis.

This is an important surgical principle: the first incision matters. An incorrect approach can complicate subsequent management, while the appropriate initial procedure can help ensure proper staging and treatment.

जब टेस्टिकुलर ट्यूमर (Testicular Tumour) का संदेह हो, तो सर्जरी का सही तरीका बहुत महत्वपूर्ण होता है। आमतौर पर अंडकोष (Scrotum) पर चीरा लगाने से बचना चाहिए, क्योंकि इससे अंडकोष की सामान्य लिम्फेटिक ड्रेनेज (Lymphatic drainage) प्रभावित हो सकती है और स्थानीय रूप से ट्यूमर कोशिकाओं के फैलने तथा बीमारी के फैलाव के तरीके में बदलाव का जोखिम बढ़ सकता है।

संदिग्ध टेस्टिकुलर कैंसर में मानक ऑन्कोलॉजिकल सर्जरी हाई इंग्वाइनल ऑर्किडेक्टॉमी (High Inguinal Orchidectomy) है। इसमें जांघ के ऊपरी हिस्से के पास इंग्वाइनल (Inguinal) रास्ते से अंडकोष को बाहर निकालकर, उसे स्पर्मेटिक कॉर्ड (Spermatic cord) तथा उसकी रक्त वाहिकाओं और लिम्फेटिक पेडिकल (Lymphatic pedicle) सहित हटाया जाता है। इससे उचित कैंसर सर्जरी सुनिश्चित होती है और सही हिस्टोपैथोलॉजिकल डायग्नोसिस (Histopathological diagnosis) में मदद मिलती है।

यह एक महत्वपूर्ण सर्जिकल सिद्धांत है: पहला चीरा बहुत मायने रखता है। गलत तरीके से किया गया पहला ऑपरेशन आगे के उपचार को जटिल बना सकता है, जबकि सही शुरुआती सर्जिकल प्रक्रिया बीमारी की उचित स्टेजिंग और आगे के उपचार में मदद करती है।

Advanced testicular cancer can still be curable, even when large residual lymph node masses remain after chemotherapy.

In this case, a 30-year-old man with a mixed germ cell tumor of the testis received systemic chemotherapy and subsequently underwent evaluation for a residual retroperitoneal lymph node mass. PET-CT showed significant residual masses measuring approximately 6 × 5 cm and 5 × 5 cm, located close to major blood vessels, including the aorta, inferior vena cava (IVC), and renal vessels.

Because of the size and location of the residual disease, surgery was technically challenging. The patient underwent exploratory laparotomy with retroperitoneal lymph node dissection (RPLND). Despite the close relationship of the tumor to the major vessels, a complete surgical resection was achieved safely, with removal of all visible residual tumor tissue.

Patient video testimonials

This video presents a compelling testimonial from a testicular cancer survivor who received life-saving treatment from Dr. Swati Shah, an expert Uro and Gynecological Oncologist. In the brief clip, the patient recounts their challenging medical journey, focusing on the critical decision-making process regarding their surgical treatment plan. Initially confronted with the difficult prospect of traditional open surgery—which typically involves a longer, more painful healing process—the patient instead opted for a state-of-the-art robotic surgery performed by Dr. Shah. The survivor shares how this advanced, minimally invasive approach made a massive difference in their overall recovery.

In the video, He speaks in Gujarati, sharing his personal experience. He explains that he initially visited the clinic because he was experiencing significant pain. After a thorough medical evaluation, he was diagnosed with cancer and advised to undergo surgical intervention. Guided by the medical expertise of Dr. Swati Shah, He confidently went ahead with the recommended operation. The surgery was a success, and he reports receiving a highly positive response to the procedure. Following the operation, his comprehensive treatment plan also included a round of chemotherapy to reduce the risk of relapse.

The patient explains that he was initially diagnosed with testicular cancer five years ago. Unfortunately, eight months prior to the video, he faced a recurrence involving a retroperitoneal lymph node. After finding Dr. Swati Shah online, he underwent a complex robotic Retroperitoneal Lymph Node Dissection (RPLND) surgery performed by her. Speaking just two months post-operation, the patient highlights his remarkably smooth and rapid recovery, noting that his follow-up medical reports have all been positive. He expresses deep gratitude and recommends Dr. Shah.

Testicular cancer case summaries

High inguinal orchidectomy for an aggressive non-seminomatous germ cell tumour

A 19-year-old man presented with rapid testicular swelling and abdominal discomfort for about two weeks. A 3.5 cm testicular lesion and a markedly raised AFP (above 1000) pointed to a high-risk non-seminomatous germ cell tumour (NSGCT), and prompt high inguinal orchidectomy was planned.

Right high inguinal orchidectomy for classical seminoma

A 36-year-old man had a hard, non-tender right testicular swelling for one year. Imaging showed a complex 7.3 × 6.3 cm lesion with raised LDH and AFP. Because of its size and possible involvement of the scrotal wall, a right high inguinal orchidectomy was performed.

Details are anonymised and shown for education only.

Patient Google reviews

★★★★★
Dr. Swati Shah operated successfully and provided excellent care throughout the treatment. She is highly skilled, compassionate, and undoubtedly the best doctor for testis cancer in Ahmedabad. We are very thankful for her guidance and expertise
Raval Prakash · Patient, Google review
★★★★★
I had an excellent experience with Dr. Swati Shah. She is one of the most skilled and compassionate doctors I have ever met. Her approach is very professional, and she explains every step of the treatment with great patience and clarity. The surgery was successful, and recovery was smooth under her guidance.
Raju Panchal · Patient, Google review
★★★★★
We had surgery done in Apollo Hospital. The doctor is very good and has done the options in a very good way. Now everything is fine.
Hiren Solanki · Patient, Google review

Testicular Cancer Evaluation in Ahmedabad

Dr. Swati H. Shah is a uro- and gynaecologic oncosurgeon in Ahmedabad with a surgical interest in testicular cancer and complex retroperitoneal disease.

For evaluation of a testicular mass, abnormal tumour markers, suspicious lymph nodes or a residual retroperitoneal mass, bring your reports and scan images for review.

Consultation: Shah’s Cancer & Robotic Surgery Centre, Gota, Ahmedabad.

Hospital: Apollo Hospital International, Ahmedabad, as appropriate.

Contact: +91 63590 11009

This page is for general education and does not replace an individual medical consultation. Imaging terms vary between radiologists and should be interpreted with the full report, images and clinical information.

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